pathology station/Renal Angiomyolipoma

Rate :
Date:
12/20/2018
Views:
79
Catgory:
Kidney

Describtion

Renal Angiomyolipoma

  • Benign tumor composed of fat, smooth muscle cells and thick-walled vessels; believe to originate from perivascular epithelioid cells (PEC) (aka, PEComa).
  • Related to other PEComas such as lymphangioleiomyomatosis, "sugar" tumor of lung, cardiac rhabdomyomas, etc.
  • May arise in association with tuberous sclerosis:
    • >50% of patients with TS develop AMLs; <50% of AML has TS.
    • Tend to be asymptomatic, bilateral, small, and multiple.
    • Associated with genetic alteration in TSC1 (chr 9q34) and TSC2 (chr 16p13.3).
  • Abundant fat containing tumor recognizable radiologically.
  • Gross:
  • Range from 1-20 cm (average 9 cm).
  • Golden-yellow appearance is common, but depends on the ratio (>fat looks like lipoma; > smooth muscle looks like leiomyoma) (image A).
  • Usually well-demarcated but not encapsulated.
  • May show local "invasion" or extension into perinephric or sinus fat.
  • Consists of varying amounts of smooth muscle cells, mature fat and thick-walled vessels 
    (image B) and (image C).
  • Vessels abnormal, often hyalinized and thick with eccentric lumen.
  • Smooth muscle cells appear to originate and "radiate" off the vessels (image D).
  • AML with benign epithelial cysts (AMLEC) is a rare variant.
  • Histology:
  • IHC: spindle cells reactive with melanoma marker (HMB-45+, Mart1+) and actin+ thereby distinguishing it from other spindle cell lesions of the kidney.
  • DDX: lipoma (for fat predominant AML), leiomyoma (for smooth muscle predominant AML).
  • Surgical intervention recommended for tumors >4 cm (retroperitoneal hemorrhage is common complication)
  •                                                                                                                                                                          
  • renal-figureA_Big.jpg

renal-figureB_Big-(1).jpg

renal-figureC_Big.jpg

renal-figureD_Big.jpg


Comments : 18

  • Austin

    12/22/2021 6:50:00 PM
    Link exchange is nothing else except it is simply placing the other person's website link
    on your page at suitable place and other person will also do same for you.
  • Bachmeier

    10/25/2021 8:13:22 PM
    Terrific work! That is the kind of info that should be shared
    around the web. Shame on Google for no longer positioning this publish higher!
    Come on over and consult with my site . Thanks =)
  • Logsdon

    9/14/2021 6:03:50 AM
    This is the perfect site for everyone who would like to find out about this
    topic. You know a whole lot its almost tough to argue with you (not that I
    personally will need to…HaHa). You definitely put a fresh
    spin on a topic which has been discussed for a long time.
    Great stuff, just great! scoliosis surgery https://coub.com/stories/962966-scoliosis-surgery scoliosis surgery
  • Coverdale

    9/4/2021 7:35:53 PM
    Heya i am for the first time here. I found this board and I find It really useful
    & it helped me out much. I'm hoping to offer something again and help others like you helped me.
  • Smithson

    8/22/2021 3:50:20 PM
    Hey There. I found your weblog using msn. This is an extremely neatly written article.
    I will be sure to bookmark it and come back to read more of your helpful information.
    Thank you for the post. I'll certainly return.
  • Agar

    8/13/2021 6:07:51 AM
    Good day! I could have sworn I've been to this blog before but
    after looking at many of the posts I realized it's new to
    me. Anyhow, I'm certainly happy I discovered it and I'll be book-marking it and checking back regularly!
  • Krimper

    5/31/2021 8:14:05 PM
    Thanks for the auspicious writeup. It in truth was a
    entertainment account it. Glance advanced to more delivered agreeable from you!
    By the way, how can we communicate?
  • Palombo

    5/31/2021 4:23:53 AM
    Having read this I believed it was really
    informative. I appreciate you spending some time and energy to
    put this article together. I once again find
    myself personally spending a significant amount of time both reading and leaving comments.
    But so what, it was still worthwhile!
  • Drayton

    5/31/2021 2:20:59 AM
    It's enormous that you are getting ideas from
    this paragraph as well as from our argument made at this place.
  • Montenegro

    5/26/2021 4:35:46 PM
    Thanks for your marvelous posting! I truly enjoyed reading it, you're a great author.

    I will ensure that I bookmark your blog and definitely will come back at
    some point. I want to encourage one to continue your great posts,
    have a nice afternoon!
  • Lowrie

    5/20/2021 4:02:00 PM
    free dating sites
    This site definitely has all of the information and facts I
    wanted concerning this subject and didn't know who to ask.

    free dating sites
  • Upchurch

    5/20/2021 1:57:02 AM
    free dating sites
    Currently it looks like Wordpress is the top blogging platform out there right now.
    (from what I've read) Is that what you are using on your blog?
    https://785days.tumblr.com/ dating sites
  • Seaborn

    4/13/2021 3:37:33 PM
    At this time I am going away to do my breakfast, after having
    my breakfast coming again to read other news. asmr
    0mniartist
  • Jersey

    4/10/2021 5:28:14 PM
    I for all time emailed this weblog post page to all my
    friends, as if like to read it after that my friends will too.
    asmr 0mniartist
  • Wickham

    7/30/2020 3:43:40 PM
    Fabulous, what a web site it is! This webpage gives helpful
    information to us, keep it up. adreamoftrains content hosting
  • Fitzgibbons

    6/28/2020 1:24:54 AM
    My brother recommended I might like this
    blog. He was totally right. This post truly made my day. You can not imagine simply how much time I had spent for this info!

    Thanks!
  • Hemming

    6/27/2020 7:42:46 PM
    Way cool! Some extremely valid points! I appreciate you penning this article and also the
    rest of the site is also very good.
  • Eldred

    6/21/2020 5:56:02 AM
    Heya i am for the first time here. I found this board and I
    find It really useful & it helped me out much. I hope to
    give something back and help others like you aided me.
  • Leave message

    Your rating:
     
    Security code